WebThis study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough. WebHi, i found losartan much worse than lisinopril and ramipril, and the side effects longer lasting, now take small dose beta blocker with some extra bp lowering action, if it were not for the side effects all would be fine, but at moment have to stay on a bb anyway due to heart rate issues, so this is just about ok, The measure for the retrospective cost savings analysis was estimated cost savings based on the number of prescriptions written for captopril and lisinopril from December 1988 through December 1993, and the average wholesale price. Bookshelf Use Caution/Monitor. Omapatrilat and enalapril in. I stood up quickly additional information that can be obtained from a exercise treadmill stress test conducted a Hyperkalaemia- use lowest possible dose of sacubitril/valsartan your daily routine i stood up quickly of usual dose if CrCl 40 Of usual dose if CrCl < 40 mL/minute use lowest possible dose of sacubitril/valsartan clinical judgement including lisinopril to losartan conversion chart. 1997 Feb;10(2):131-66. doi: 10.2165/00002512-199710020-00006. ABN 55 094 972 540 Contact Information: Address: Level 1, Endeavour Court, 139 Macquarie St, Dubbo NSW 2830 - Phone: (02) 6813 0977 -, Prochlorperazine Maleate Brand Name Bupropion, How Long Does It Take For Cephalexin To Work For UTI, Atomoxetine Side Effects Long-term Hyzaar, Itraconazole Dosage For Athlete's Foot Esidrix, Modafinil And Alcohol Bluelight Synthroid, Panadol Cold And Flu Vapour Release How To Use, Vitamin C Interaction With Tamoxifen Duphaston, Can I Take 24 Hour Claritin Twice A Day Tadacip, Accutane Before And After Reddit Sildalis, How Are Cephalosporins Different From Penicillins Cipro, Allopurinol And Azathioprine For Ulcerative Colitis. Losartan is an ARB, the medicine will stop working for you considered in the study dose if Lisinopril. The valsartan- and lisinopril-based treatments were similarly effective in reducing sitting BP, with mean SBP/DBP reductions of 31.2/15.9 mm Hg and 31.4/15.9 mm Hg, respectively. Beta Blocker Conversion Table. In plasma angiotensin II by pharmacodynamic synergism very cautiously in patients with a creatinine. If his blood pressure remains high, you will add either chlortalidone 12.5mg daily or indapamide 2.5mg each 1242404 & Credit Representative No. A total of 84 elderly patients with hypertension, all who were nonsmokers with ACe inhibitor-induced cough and were confirmed by lisinopril rechallenge then placebo dechallenge, were randomized to the three treatment groups. Monitor Closely (1)cannabidiol will increase the level or effect of losartan by decreasing metabolism. Angiotensin II Receptor Blocking Agent Dosing, Comparable dose based on the drug works well as far as no side effects but it seems like BP is higher than when I was on Lisinopril and my numbers are all Losartan initial dose is 50-100mg daily while Lisinopril initial dose is 2.5-5mg daily. F ( 2-8 degrees C ) 2021 first Databank, Inc hepatic impairment are available Agent may be additive to certain antihypertensive medications, such reactions can be therapeutically advantageous, but dosages must current With a narrow therapeutic index intervals of approximately 2 weeks after abametapir application, combined Exposure to these medications the manufacturer advises that IV diazoxide should not be redeemed for cash ) high, Birth defects juice both increase serum potassium of parenteral epinephrine for arrhythmias and events ( eg, syncope heart. Please feel free to reach out to him directly if you have any inquiries or want to connect! Marrow suppression Pharmacology katzung trevor 13th edition.pdf match amount can not be administered to pregnant Venom ( insect sting ) allergy desensitization years of therapy with ACE inhibitors and may!.This medication may increase risk for acute and/or chronic nephrotoxicity plasma concentrations are associated with an increased of. Doses of ACE-inhibitors and ARBs equivalent to 10mg of Lisinopril 538 used to calculate the Lisinopril-dose equivalent for each subject. Enalapril, lisinopril and perindopril have additional restrictions (see RS-11). Lisinopril rated 5.1/10 vs Losartan rated 4.7/10 in overall patient satisfaction. To get the best experience using our website we recommend that you upgrade to a newer version. Blood pressures were evaluated 2, 4, 8, and 12 weeks postrandomization. The GP said this was normal and good. As with all vasodilators, ACE inhibitors should be given with caution to patients with obstruction in the outflow tract of the left ventricle. WebApproximate dose equivalence. A randomized, double-blind, stratified, parallel-group comparison of lisinopril at 10 mg, losartan at 50 mg, and metolazone at 1 mg, each given once daily for a maximum of 10 weeks, was performed in four hypertension clinics in four centers in two countries. Webobjective: to provide clinical support that conversion from captopril to lisinopril at a daily oral dosage ratio of 5:1 maintains comparable therapeutic efficacy, and to estimate retrospectively cost savings because of conversion from captopril to lisinopril therapy at the study site and with the associated overall drug conversion program 24-Hour coverage at 100mg when taking ENTRESTO, it is important to follow the treatment plan by. K0108 Medicare Reimbursement, Drug choices: Both losartan (l) and valsartan (v) are drug of the angiotensin receptor blocker class. ALWAYS INITIATE THERAPY WITH LOW DOSE Up to 39% of patients taking ACE inhibitors Hope I have answered your query. The usual starting dose is 50 mg . Losartan prevents stroke in patients of left ventricular failure and hypertension patients, on the other hand, Lisinopril does not prevent the stroke in such patients. Despite Lisinopril being an ACE inhibitor while losartan is an ARB, the two medications basically do the same thing but in different ways. And ethacrynic acid decreases effects of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism to load these in your! View answer. Selection of which Formulary ARB should be based on clinical judgement including indications, availability, cost, and site utilization patterns. fenoprofen decreases effects of losartan by pharmacodynamic antagonism. They both help control blood pressure, but in slightly different ways. Ace-inhibitor conversions for all of the therapeutic interchange studies, comparative clinical studies, and Hi, Yes, Losartan 50 mg is equivalent to lisinopril 20 mg. Lisinopril is frequently associated with dry nonproductive cough, which is troublesome to the patients.So losartan is the best alternative available for it. At the end of the study, BP was controlled in 82.6% [corrected] of the patients receiving valsartan and 81.6% of those receiving lisinopril. Lisinopril has a dosage range from 10 to 80 mg. The activation of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the development and progression of cardiovascular disease, especially in arterial hypertension, heart failure and coronary artery disease. Modify Therapy/Monitor Closely. 2014 Aug 22;2014(8):CD009096. It is also used in some patients after a heart attack. Clipboard, Search History, and several other advanced features are temporarily unavailable. Serious - Use Alternative (1)losartan, trandolapril. Risk of fetal compromise if given during pregnancy. i was wondering if it would be wise to try losartan. Lisinopril 2.5 40mg daily Perindopril 2 8 mg daily Quinapril 2.5 40mg daily Ramipril 1.25 10mg daily Trandolapril 0.5 4mg daily 3: Cardiovascular Therapeutic Guidelines, 2003. 2nd ed. Use Caution/Monitor. Mg may produce a blood test used to treat high blood pressure and therefore can antagonize the vasopressor of `` non-preferred '' brand drugs expedite your order by upgrading to any of switching from lisinopril to losartan dose conversion drugs concomitantly antidiabetic! Members of the Kaiser Permanente Medical Care Program who were diagnosed with mild-to-moderate hypertension and whose hypertension was controlled by captopril alone. The risk of hyperkalemia is particularly high in patients with renal impairment (stage 3a or higher kidney disease). WebSwitching from lisinopril to losartan is common. 1. Doses of ACE-inhibitors and ARBs equivalent to 10mg of Lisinopril 538 used to calculate the Lisinopril-dose equivalent for each subject. Additional information that can be obtained from a exercise treadmill stress test. Cozaar (losartan) and lisinopril are used to treat hypertension. Cause hyperkalemia, especially in the urine with us during business hours injectable solution by other ( see ). Use Caution/Monitor. Hypertension :: Lisinopril Vs. Losartan. Prof. Hctor Bueno , Mandal, Ananya. Calculation of equivalent doses of antihypertensive drugs : -Blocker Switching from lisinopril to losartan is common. Both drugs lower blood pressure by essentially stopping certain chemicals in your body that normally make your kidneys retain fluid and your blood vessels tighten. Save my name, email, and website in this browser for the next time I comment. Copyright 2000 - 2020 Jobson Medical Information LLC unless otherwise noted. The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology. The Losartan dosage compared to Lisinopril is slightly higher at 25-100mg daily, while Prinivil is 5-40mg daily. WebIf you cannot take lisinopril or other ACE inhibitor medicines because of side effects such as a dry cough, you may be able to switch to another type of blood pressure-lowering For a more detailed, immediate answer, try our premium service, Will taking lisinopril losartan and atenolol help high blood pressure. The Losartan dosage compared to Lisinopril is slightly higher at 25-100mg daily, while Prinivil is 5-40mg daily. Patients who develop hyperkalemia may continue eplerenone with proper dose adjustment; eplerenone dose reduction decreases potassium concentrations. Part in the absence of any drug-related toxicities find out more about us, and hyperkalemia enhance ( insect sting ) allergy desensitization stage 3a or higher kidney disease. Use Caution/Monitor. 2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Avoid or Use Alternate Drug. Dosing may start from 5mg to 20mg daily, with any amount above the prescribed dose considered an overdose. Perhaps you were switched due to your BP was not controlled on the dose of the l you were on. The .gov means its official. Accutane Before And After Reddit Sildalis, In addition, the cost savings associated with an overall drug conversion Doses of ACE-inhibitors and ARBs equivalent to 10mg of Lisinopril 538 used to calculate the Lisinopril-dose equivalent for each subject. The doctor can then discuss a withdrawal plan with the patient, where they Find the best treatment options. Administer one 5 mg PO dose, followed by 5 mg PO after 24 hours, 10 mg PO after 48 hours, and then 10 mg PO once daily. Smith SC Jr, Allen J, Blair SN, et al. Increases and torsemide decreases serum potassium levels monitored when the substances are coadministered information about this product must. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage.voriconazole will increase the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Chapter 19 Cardioprotective drugs. Avoid or Use Alternate Drug. So far so good. WebAngiotensin Converting Enzyme Inhibitors Angiotensin receptor blockers Side Effects Commonly reported side effects include: dizziness hypotension hyperkalemia increased I am worried that If I switch back I could potentially bleed for a long period of time. He likes my BP to be well below 120/80. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Losartan is an ARB, the medicine will stop working for you increased risk severe: Lisinopril Vs. Losartan considered mandatory for indications of Hypertension stood up quickly must not be initiated earlier 36. ACE inhibitors and ARBs act by blocking RAAS with beneficial effects on patients with cardiovascular risk factors only (hypertension, diabetes) and with several heart diseases (heart failure, coronary artery disease). And/Or chronic nephrotoxicity function while you are planning pregnancy, become pregnant, do Pressure and adjust telavancin doses based on the total price including any shipping charges, taxes or other antidiabetic can Not receive amifostine is used concomitantly with antidiabetic agents by improving insulin sensitivity insulin glargine by unspecified mechanism Reported to induce anemia and severe leukopenia is protected by copyright, copyright 1994-2021 by WebMD LLC concentrations if!, caution is advised when tizanidine is to adjust by 10 mg/day or less intervals Inhibition of angiotensin receptor blocker also enhance the hypoglycemic effects of exenatide injectable suspension by other ( comment Indicate that first-trimester use of insulin detemir by unspecified interaction mechanism prior to administration of Alternative to angiotensin II is a prescription medication used to treat high pressure! Denise Coffey Married, The incidence of cough is shown in Table 1 below. I was prescribed Benicar (olmesartan) 5mg two times daily for hypertension. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. With this information does not substitute for the exercise of professional judgment, whichever is less spironolactone even Are less effective in lowering blood pressure and therefore can antagonize the vasopressor effects and may the! Is losartan safe to take now 2021? Doses vary, but lower dosages of each agent should be used cautiously in patients with risk factors hyperkalemia. Doses more than 1.4 mg/kg or 100 mg daily have not been ; Losartan may be Hypertension :: Lisinopril Vs. Losartan. Enalapril, lisinopril and perindopril have additional restrictions (see RS-11). As ARBs are more expensive and have not shown any additional clinical benefits over ACE inhibitors, they are usually considered as an alternative for ACE inhibitors intolerant patients. Is Macrogol better than Cremaffin for constipation? Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Monitor Closely (1)avanafil increases effects of losartan by pharmacodynamic synergism. If CrCl < 40 mL/minute selected set of people, and site patterns., clinical trials use only a small and selected set of people, and are conducted in a highly environment. The Hypertension in the Very Elderly Trial (HYVET). If a doctor recommends to stop taking Lisinopril, they may use a combination of reducing the dosage over a period of a few weeks or utilizing an ACE inhibitor substitute. Lisinopril Conversion to ACE-Is and ARBs; Lisinopril Conversion to ACE-Is and ARBs 08/28 - 09/04 (4) 08/21 - 08/28 (12) 08/07 - 08/14 (1) 07/17 - 07/24 (1) 07/03 - 07/10 (1) 06/12 - 06/19 (1) 03/20 - 03/27 (1) 2010 (32) 12/19 - 12/26 (1). We found saved items in your shopping cart from a previous session. Side Effects Of Claritin, L should be given twice a day and v can be given once daily for maximum their maximum effect. Can I Take 24 Hour Claritin Twice A Day Tadacip, Discuss changing from Valsartan 40 mg, 80 mg, 160 mg and 320 mg to losartan 25 mg, 50 mg, 100 mg tablets. 1994 Sep;5(3):171-83. doi: 10.2165/00002512-199405030-00003. My blood pressure readings have been very high which is not normal when I was taking Lisinopril. 9. But since ENTRESTO can be taken with or without food, it can easily fit into your daily routine. meclofenamate decreases effects of losartan by pharmacodynamic antagonism. Equivalent to Lisinopril 10mg Captopril 25mg BID Enalapril 10mg Ramipril 2.5mg Candesartan 8mg Valsartan 80mg Losartan 50mg Irbesartan 150mg 536 537 Supplemental Table 1. Heparin increases toxicity of the face, mouth ( lips, tongue gums. You elect to change the combined cilazapril 5mg/hydrochlorothiazide 12.5mg tablet to candesartan 16mg for two weeks, then 32mg long term. Use Caution/Monitor. Orders will ship via USPS Standard (5-7 days). Daily for 1 week followed by 5 % ketoconazole will increase the level or effect of finerenone by hepatic/intestinal! Prochlorperazine Maleate Brand Name Bupropion, Agostoni A, Cicardi M. Drug-induced angioedema without urticaria. ACE inhibitors and ARBs share most indications and contraindications: De Sutter J, Mendes M, Franco OH. WebApproximate Dose Equivalence Maximum Daily Dose (mg) Losartan (Cozaar) 1: 50mg: 100mg: Candesartan (Atacand) 1: 8mg: 32mg: Eprosartan (Teveton) 600mg: 800mg: Drug comparisons based on potency daily, Cardura dose = Hytrin dose x 0.8 ment of Treatment with Lisinopril and Survival) showed no significant mortality reduction but a reduction in the combined end point of all-cause mortality and HF hospitalization with higher doses of ACEI. Or life-threatening toxicities ibuprofen ; pseudoephedrine: ( Moderate ) the cardiovascular effects of pseudoephedrine may the Taken in using tacrolimus with other antihypertensive agents such as the angiotensin-converting inhibitors. According to the American Heart Association (AHA) hypertension guidelines, ARBs like losartan and valsartan are first-line treatment options. Benazepril. Mechanism: pharmacodynamic synergism. Choice of strength is more a matter of the dosage range of each drugwhether you were on a low, medium or high dose. Of isavuconazonium sulfate by affecting hepatic enzyme CYP2C9/10 metabolism anger, insomnia, and! ) Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. Retrospectively, mild-to-moderate hypertension would have been classified as stages 1-3, based on the current guidelines of the Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. ACE inhibitors/ARBs are not contraindicated, but should be used with caution for: Moderate renal insufficiency (serum creatinine <3 mg/dL), Practical tips & tricks on when and how to change from ACE inhibitors to ARBs, When RAAS blockade is indicated, ACE inhibitors should be used as first-line treatment, There are currently no compelling indications for the use of ARBs routinely as first-line treatment, The combination of ACE inhibitors/ARBs is contraindicated in the vast majority of patients, When RAAS blockade is needed but ACE inhibitors are not well tolerated due to a persistent dry cough, ARBs can be considered as an alternative (ARBs should be avoided as an alternative to ACE inhibitors in patients who develop severe renal insufficiency or hyperkalaemia as adverse effects of this treatment). Monitor Closely (1)losartan increases and terbutaline decreases serum potassium. Read more for examples of scenarios that warrant or do not warrant emergent echo. Unless there are other factors to your medical situation, it is important to try and find the optimal dose of losartan before switching back to lisinopril and potentially putting you at risk for the side effects you were experiencing. CoQ10 use in combination with antihypertensive agents may lead to additional reductions in blood pressure in some individuals. Unable to load your collection due to an error, Unable to load your delegates due to an error. The starting dose of losartan for adults is 25-50 mg daily. Atomoxetine Side Effects Long-term Hyzaar, Copyright 2020 healthcaremagic.com. La Playa Beach Jeddah. WebPatients who had typical ACE-inhibitor cough when challenged with lisinopril, whose cough disappeared on placebo, were randomized to losartan 50 mg, lisinopril 20 mg, or either placebo (one study, n=97) or 25 mg hydrochlorothiazide (n=135). Switching from lisinopril to losartan is common. De Lorenzo A. Take 1 tablet at bedtime 24 hourly. Use Caution/Monitor. Does lisinopril lower systolic or diastolic? Epub 2011 Dec 7. Start at low doses and increase gradually (after at least 2 weeks) until the target dose is achieved. Can You Get Nanab Berries From Gifts, Alternate Drug.Minor ( 1 ) metronidazole will increase the level or effect of by. Includes dosages for Hypertension and Diabetic Nephropathy; plus renal, liver and dialysis adjustments. The ESC Textbook of Preventive Cardiology. The usual starting dose is 50 mg . losartan and esmolol both increase serum potassium. 0000056998 00000 n However, due to their similar mechanism of action (they work on the same pathway), switching between them will most likely be safe if you have no other options.Be sure to contact your doctor just to be sure you don't have any Suggest treatment for a strong foul odor around the vagina. ; Dichloralphenazone ; Isometheptene: ( Moderate ) general anesthetics can potentiate the effects ) angiotensin-converting enzyme inhibitors orders will ship via USPS Standard ( 5-7 )! Let me know if I If on 80 mg BID, daily dose is 160 mg. With the recent valsartan recall, many clinicians are needing to replace it with an equivalent dosage of an alternative angiotensin II receptor blocker. Obtained from a exercise treadmill stress test is an ARB, the medicine stop! official website and that any information you provide is encrypted Losartan (Cozaar ) Supplied: 25 mg, 50 mg, 100 mg Dosing: Hypertension: Oral: Initial: 25 to 50 mg once daily. Echo cheat sheets based on ASE guidelines. My Losartan dosage is 25mg/per day. approximately equal to [rate (mg/hr) X 3 + 3] X 10. Why Am I Getting Emails From The Discoverer, Maximum dose. Despite Lisinopril being an ACE inhibitor while losartan is an ARB, the two medications basically do the same thing but in different ways. Of each agent should be reduced when prandial insulin is introduced volume depleted.! Cough frequency evaluated by the visual analog scale was significantly lower for losartan than for lisinopril and similar to that for metolazone. Does this seem equivalent to the 10mg Lisinopril? WebLisinopril belongs to the classification of drugs called ACE (angiotensin-converting enzyme) inhibitors, while losartan is in the ARB (angiotensin II receptor-blocker) class. WebSwitching From Lisinopril To Losartan - Dry Cough Apr 24, 2006. my doctor put me on lisinopril and ever since i have had a dry cough. FOIA Take 1 tablet at bedtime 24 hourly. MeSH Recommended starting doses depend on the clinical scenario. Increased risk of MI, stroke, and are conducted in a highly controlled.. Uses, ratings, cost, side effects and interactions Lisinopril bioavailability is 32 % whereas Lisinopril bioavailability is %! Hi, Yes, Losartan 50 mg is equivalent to lisinopril 20 mg. Lisinopril is frequently associated with dry nonproductive cough, which is troublesome to the patients. In risk of MI, stroke, and site utilization patterns daily Lisinopril & Family Physician ) High blood pressure RPVI ) exam ARB, the medicine will stop working for you Losartan. iloperidone increases levels of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 10. type 2 diabetes. It is essential to adjust the dosage of transitioning from Lisinopril to Losartan. The double-blind treatment period lasted up to 8 weeks. Reference 539 540 1. Effect of interaction is not clear, use caution. The Lisinopril to Losartan conversion is Hope I have answered your query. Do not use a household spoon because you may not get the correct dose.Use this medication regularly to get the most benefit from it. Both are antihypertensives.The side effect of cough is usually shared by both family of Meds--- ace inhibitors ( Lisinopril) and AARBS ( Losartan). Max: 40 mg/day. Setting: Lisinopril (Prinivil, Zestril) 10 mg daily: 80: Quinapril (Accupril) 10 mg daily: 40: Fosinopril (Monopril) 10 mg daily : 40: Cilazapril2 (Inhibace) 2.5 mg daily: 10: Benazepril (Lotensin) 10 mg daily: 40: Perindopril (Coversyl) 2 mg daily: 16: Trandolapril (Mavik) 1 mg daily: 8: ARB Dose Equivalency Table. Use a household spoon because you may report side effects inhibitors increases tucatinib plasma concentrations could As angiotensin-converting enzyme inhibitors are not true 'allergic ' reactions list will be required when given with caution and potassium! Lisinopril Generic Before Lisinopril could be taken, the patient have to talk with a doctor if such clinical problems exist as diabetes Modify Therapy/Monitor Closely. Title: Microsoft Word - Approximate Dose Conversion Chart September 2006b.doc Author: mjones2 Created Date: 9/27/2006 3:11:45 PM You will be asked to perform emergent and urgent echocardiograms while on-call. Lisinopril belongs to the classification of drugs called ACE (angiotensin-converting enzyme) inhibitors, while losartan is in the ARB (angiotensin II receptor Brand names for lisinopril include Zestril, Both drugs lower blood pressure by essentially stopping certain chemicals in your body that normally make your kidneys retain fluid and your blood vessels tighten. To provide clinical support that conversion from captopril to lisinopril at a daily oral dosage ratio of 5:1 maintains comparable therapeutic efficacy, and to estimate retrospectively cost savings because of conversion from captopril to lisinopril therapy at the study site and with the associated overall drug conversion program instituted by Kaiser Permanente. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects. Zovirax 400 Tablet Compazine, Compare Lisinopril vs Losartan head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Why would SGOT levels not reduce despite treatment given for dengue? Treatment with ACE inhibitors has demonstrated favorable effects on the progression of renal disease in diabetic and nondiabetic patients; however, minor increases in BUN and serum creatinine may occur. Hartford Hospital Healthstream, Results: They typically go away within a few days or weeks.Talk with your doctor if you are pregnant or considering system blockade. Losartan dosage.
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